Sepsis

Infections, Sudden illness and injury.

How common is Sepsis in the US?

Adult hospitalizations with a sepsis diagnosis (ICD-10-CM), National Inpatient Sample: 2.96 million (Adult sepsis hospitalizations, United States, National Inpatient Sample, 2022 (count, not an incidence rate); United States (National Inpatient Sample, nationally representative database), 2022). Source: BMC nephrology, 2026. Label: REPORTED.

• 2.96 million Adult hospitalizations with a sepsis diagnosis (ICD-10-CM), National Inpatient Sample. Out of: Adult sepsis hospitalizations, United States, National Inpatient Sample, 2022 (count, not an incidence rate). Where: United States (National Inpatient Sample, nationally representative database). When: 2022. Hospitalized adult sepsis cases only; excludes pediatric sepsis and sepsis that does not result in hospitalization. Label: REPORTED.

  Among an estimated 2.96 million adult sepsis hospitalizations in 2022, 44.5% involved AKI.

  Source: Clinical and resource burden of acute kidney injury among adults hospitalized with sepsis: a retrospective cross-sectional study. BMC nephrology, 2026. PubMed 41877057. DOI 10.1186/s12882-026-04915-z.

Each figure measures something different. Do not compare them with each other or with other conditions.

Medical codes

• ICD-10-CM FY2026: A41.9 Sepsis, unspecified organism (narrower). Other codes in this category also apply.
• ICD-10-CM FY2026: A41.51 Sepsis due to Escherichia coli [E. coli] (narrower). Other codes in this category also apply.

Research activity

As of 2026-09-24: 3,821 registered studies on ClinicalTrials.gov (search Sepsis) and 43,076 PubMed records, 2021 to 2025. A count of records is not how common or serious the condition is.

Population information, not medical advice. Methodology · Known limitations