Osteogenesis imperfecta

Rare, genetic, and present at birth. Also called: Brittle bone disease.

How common is Osteogenesis imperfecta in the US?

US pediatric inpatient hospital admissions listing osteogenesis imperfecta as a diagnosis: 7291 admissions (Hospital admissions over 1997-2016, not a rate; nationally representative sample of US pediatric hospital discharges; United States (HCUP Kids' Inpatient Database, a nationally representative sample of pediatric hospital discharges), 1997-2016). Source: The Journal of Pediatrics, 2024. Label: REPORTED.

• 7291 admissions US pediatric inpatient hospital admissions listing osteogenesis imperfecta as a diagnosis. Out of: Hospital admissions over 1997-2016, not a rate; nationally representative sample of US pediatric hospital discharges. Where: United States (HCUP Kids' Inpatient Database, a nationally representative sample of pediatric hospital discharges). When: 1997-2016. Counts inpatient hospital admissions listing OI as a diagnosis over a 20-year span, not total US OI cases or births; a single patient can contribute multiple admissions. Label: REPORTED.

  There were 7291 admissions that listed OI as a diagnosis in the Kids' Inpatient Database from 1997 through 2016.

  Source: National Trends in Inpatient Hospital Outcomes of Children with Osteogenesis Imperfecta and the Importance of Extraskeletal Manifestations: A Kids' Inpatient Database Study. The Journal of Pediatrics, 2024. PubMed 38945443. DOI 10.1016/j.jpeds.2024.114174.

Each figure measures something different. Do not compare them with each other or with other conditions.

Medical codes

• ICD-10-CM FY2026: Q78.0 Osteogenesis imperfecta (exact)

Research activity

As of 2026-09-24: 93 registered studies on ClinicalTrials.gov (search Osteogenesis Imperfecta) and 1,274 PubMed records, 2021 to 2025. A count of records is not how common or serious the condition is.

Population information, not medical advice. Methodology · Known limitations