Neonatal abstinence syndrome

Pregnancy, birth, and newborn, Children and teens, Mental health and substance use. Also called: NAS.

How common is Neonatal abstinence syndrome in the US?

Estimated US neonatal abstinence syndrome (NAS) rate per 1000 birth hospitalizations, 2017: 7.3 (US birth hospitalizations (rate per 1000 birth hospitalizations); United States (HCUP National Inpatient Sample and State Inpatient Databases, 47 states plus DC), 2017 (trend period 2010-2017)). Source: JAMA (HRSA/CDC/AHRQ), 2021. Label: VERIFIED.

• 7.3 Estimated US neonatal abstinence syndrome (NAS) rate per 1000 birth hospitalizations, 2017. Out of: US birth hospitalizations (rate per 1000 birth hospitalizations). Where: United States (HCUP National Inpatient Sample and State Inpatient Databases, 47 states plus DC). When: 2017 (trend period 2010-2017). Label: VERIFIED.

  From 2010 to 2017, the estimated NAS rate significantly increased by 3.3 per 1000 birth hospitalizations (95% CI, 2.5-4.1), from 4.0 (95% CI, 3.3-4.7) to 7.3 (95% CI, 6.8-7.7).

  Source: Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses in the US, 2010-2017 JAMA (HRSA/CDC/AHRQ), 2021. PubMed 33433576. DOI 10.1001/jama.2020.24991.

Each figure measures something different. Do not compare them with each other or with other conditions.

Medical codes

• ICD-10-CM FY2026: P96.1 Neonatal withdrawal symptoms from maternal use of drugs of addiction (exact)

Research activity

As of 2026-09-24: 71 registered studies on ClinicalTrials.gov (search Neonatal Abstinence Syndrome) and 449 PubMed records, 2021 to 2025. A count of records is not how common or serious the condition is.

Population information, not medical advice. Methodology · Known limitations