Treatment-Resistant Depression

Treatment-Resistant Depression is indexed under Mental Health & Behavioral, Mood Disorders. Also known as TRD.

US prevalence

~30% of MDD patients (~5.5-7 million) Source: NIMH; STAR*D trial data. Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

F32.9, F33.9

Typical onset

Follows MDD demographics

Course

managed

Body systems

psychiatric

Sex differences

Follows MDD demographics

Racial and ethnic differences

May be higher in underserved populations with less treatment access

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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