Spinal Muscular Atrophy

Spinal Muscular Atrophy is indexed under Neurological & Neurodegenerative, Motor Neuron Disease. Also known as SMA.

US prevalence

~1 in 10,000 newborns are affected by spinal muscular atrophy Source: NINDS — Nusinersen (Spinraza) contribution-to-therapies overview. Federal source. Label: VERIFIED.

ICD-10-CM codes

G12.0, G12.1

Typical onset

SMA1: <6 months; SMA2: 6-18 months; SMA3: >18 months; SMA4: adult

Course

progressive

Body systems

neurological, musculoskeletal, pulmonary

Sex differences

Equal (autosomal recessive)

Racial and ethnic differences

Carrier frequency varies: ~1 in 40-60 depending on ancestry

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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