Scleroderma / Systemic Sclerosis

Scleroderma / Systemic Sclerosis is indexed under Musculoskeletal & Connective Tissue, Systemic Autoimmune. Also known as SSc, systemic sclerosis, CREST syndrome.

US prevalence

~100,000 (~24 per 100,000) Source: Scleroderma Foundation; ACR. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

M34, M34.9

Typical onset

25-55 years; peak 30-50

Course

progressive

Body systems

dermatologic, pulmonary, gastrointestinal, cardiovascular, renal

Sex differences

F:M ~4:1

Racial and ethnic differences

More common and more severe in Black women; Choctaw Native Americans also high risk

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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