Post-Treatment Lyme Disease Syndrome

Post-Treatment Lyme Disease Syndrome is indexed under Infectious-Origin Chronic, Post-Infectious. Also known as PTLDS, chronic Lyme disease (controversial term), chronic Lyme disease.

US prevalence

~10-20% of 476,000 annual Lyme cases develop persistent symptoms; estimated 1-2 million cumulative Source: CDC 2022; NEJM 2022; Johns Hopkins Lyme Center | CDC; NIH NIAID (contested). Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

A69.20

Typical onset

Any age post Lyme infection; more recognized in endemic Northeast/Upper Midwest

Course

managed

Body systems

neurological, musculoskeletal, immune

Sex differences

Roughly equal

Racial and ethnic differences

Primarily affects populations in Lyme-endemic regions; underrecognized in Black patients

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

Browse all indexed conditions · Source registry · Methodology · Known limitations