Neurofibromatosis

Neurofibromatosis is indexed under Rare / Orphan Chronic, Neurocutaneous Syndromes. Also known as NF1, NF2, von Recklinghausen disease.

US prevalence

NF1 occurs in ~1 in 3,000-4,000 people worldwide; NF2 has estimated incidence ~1 in 33,000. These are distinct disorders and should not be collapsed into one U.S. count Source: NIH MedlinePlus Genetics — Neurofibromatosis type 1 and type 2. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

Q85.0

Typical onset

NF1: childhood; NF2: teens-20s

Course

lifelong

Body systems

neurological, dermatologic, musculoskeletal

Sex differences

Equal (autosomal dominant)

Racial and ethnic differences

Pan-ethnic

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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