Mixed Connective Tissue Disease

Mixed Connective Tissue Disease is indexed under Autoimmune & Inflammatory, Overlap Syndromes. Also known as MCTD, Sharp syndrome.

US prevalence

~10 per 100,000 Source: ACR; NIH. Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

M35.1

Typical onset

15-35 years

Course

progressive

Body systems

musculoskeletal, pulmonary, gastrointestinal

Sex differences

F:M ~9:1

Racial and ethnic differences

Limited data

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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