Major Depressive Disorder
Major Depressive Disorder is indexed under Mental Health & Behavioral, Mood Disorders. Also known as MDD, clinical depression, unipolar depression.
- US prevalence
- ~19.7 million adults (7.4%) had a past-year major depressive episode in 2025 Source: SAMHSA, National Survey on Drug Use and Health, 2025 NSDUH Annual National Report, published July 27, 2026. Federal source. Label: VERIFIED.
- ICD-10-CM codes
- F32, F33
- Typical onset
- Peak onset 18-25; can occur at any age
- Course
- episodic
- Body systems
- psychiatric
- Sex differences
- F:M ~2:1
- Racial and ethnic differences
- Reported rates lower in Black and Hispanic adults (may reflect underdiagnosis/cultural factors)
What this page does not establish
These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.
Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.
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