Hereditary Transthyretin Amyloidosis (Polyneuropathy)

Hereditary Transthyretin Amyloidosis (Polyneuropathy) is indexed under Rare / Orphan Chronic, Protein Misfolding. Also known as hATTR, familial amyloid polyneuropathy, FAP.

US prevalence

~50,000 worldwide; US estimates unclear; Val30Met and Val122Ile most common Source: Amyloidosis Foundation. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

E85.1

Typical onset

Val30Met: 30s-40s (Portuguese); Val122Ile: >60 (Black Americans)

Course

progressive

Body systems

neurological, cardiovascular

Sex differences

Equal genetic; Val30Met more symptomatic in men

Racial and ethnic differences

Val122Ile carried by ~3-4% of Black Americans

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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