Hereditary Angioedema

Hereditary Angioedema is indexed under Rare / Orphan Chronic, Complement Disorders. Also known as HAE, C1 inhibitor deficiency.

US prevalence

Estimated worldwide frequency ~1 in 50,000 people; no U.S.-specific national count identified Source: NIH MedlinePlus Genetics — Hereditary angioedema. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

D84.1

Typical onset

Childhood/adolescence; attacks often worsen at puberty

Course

episodic

Body systems

immunologic, dermatologic, gastrointestinal

Sex differences

Equal genetic; women may have more severe attacks (hormonal triggers)

Racial and ethnic differences

Pan-ethnic

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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