Hereditary Hemochromatosis

Hereditary Hemochromatosis is indexed under Rare / Orphan Chronic, Iron Metabolism. Also known as HH, iron overload disease.

US prevalence

Type 1 hereditary hemochromatosis affects about 1 million people in the United States; the broader hereditary-hemochromatosis category includes rarer types and should not inherit that count Source: NIH MedlinePlus Genetics — Hereditary hemochromatosis. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

E83.11

Typical onset

Men: symptoms 40-60; Women: post-menopause

Course

managed

Body systems

hepatic, cardiovascular, endocrine

Sex differences

Clinical disease M:F ~5-8:1 (women protected by menstrual iron loss)

Racial and ethnic differences

Primarily Northern European/Celtic descent; C282Y homozygosity ~1 in 200 in this group

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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