Fabry Disease

Fabry Disease is indexed under Rare / Orphan Chronic, Lysosomal Storage Disorders. Also known as Anderson-Fabry disease, alpha-galactosidase A deficiency.

US prevalence

~1 in 40,000-117,000 males; heterozygous females also affected Source: NIH NINDS; Fabry Support & Information Group. Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

E75.21

Typical onset

Males: childhood (classic); later-onset variants in adults

Course

progressive

Body systems

renal, cardiovascular, neurological, dermatologic

Sex differences

X-linked; males more severe; heterozygous females variable

Racial and ethnic differences

Pan-ethnic

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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