Common Variable Immunodeficiency

Common Variable Immunodeficiency is indexed under Autoimmune & Inflammatory, Primary Immunodeficiency. Also known as CVID.

US prevalence

~1 in 25,000-50,000 (~8,000-12,000) Source: IDF; NIH NIAID. Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

D83.9

Typical onset

Often diagnosed 20-40; second peak in childhood

Course

lifelong

Body systems

immunologic, pulmonary, gastrointestinal

Sex differences

Roughly equal

Racial and ethnic differences

Primarily described in white populations; likely underdiagnosed in others

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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