Cold Agglutinin Disease

Cold Agglutinin Disease is indexed under Hematologic, Autoimmune Hemolytic Anemia. Also known as CAD.

US prevalence
~16 per million Source: ASH. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.
ICD-10-CM codes
D59.12
Typical onset
Primarily >60
Course
managed
Body systems
hematologic
Sex differences
Roughly equal
Racial and ethnic differences
Limited data

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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