Cardiac Amyloidosis

Cardiac Amyloidosis is indexed under Cardiovascular, Infiltrative Cardiomyopathy. Also known as amyloid cardiomyopathy, ATTR-CM.

US prevalence

ATTR-CM possibly 300,000-500,000 (vastly underdiagnosed) Source: AHA 2023; amyloidosis literature. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

E85.4, I43

Typical onset

ATTR-CM: >65; AL cardiac: 50-70

Course

progressive

Body systems

cardiovascular

Sex differences

ATTR-CM M:F ~3-4:1

Racial and ethnic differences

Val122Ile variant in ~3-4% of Black Americans

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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