Antiphospholipid Syndrome

Antiphospholipid Syndrome is indexed under Autoimmune & Inflammatory, Systemic Autoimmune. Also known as APS, Hughes syndrome, lupus anticoagulant syndrome.

US prevalence

~1-5% of general population have aPL antibodies; clinical APS ~40-50 per 100,000 Source: ACR; NIH NHLBI. Cites federal and non-federal sources, and the record does not say which one gave this figure. Label: REPORTED.

ICD-10-CM codes

D68.61

Typical onset

20-50 years; often diagnosed after thrombotic event or pregnancy loss

Course

lifelong

Body systems

hematologic, cardiovascular, neurological, reproductive

Sex differences

F:M ~5:1

Racial and ethnic differences

May be more common in Black Americans

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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