Amyloidosis (AL, ATTR)

Amyloidosis (AL, ATTR) is indexed under Rare / Orphan Chronic, Protein Misfolding. Also known as AL amyloidosis, transthyretin amyloidosis, ATTR-CM, ATTR.

US prevalence

AL: ~4,500 new/year; ATTR-CM: potentially 300,000-500,000 (underdiagnosed) Source: Amyloidosis Foundation; AHA. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.

ICD-10-CM codes

E85.1, E85.4, E85.8

Typical onset

AL: 50-70; ATTR-CM: >65; hereditary ATTR: 30-70

Course

progressive

Body systems

cardiovascular, renal, neurological, gastrointestinal

Sex differences

ATTR-CM: M:F ~3-4:1

Racial and ethnic differences

Hereditary ATTR (Val122Ile): ~3-4% of Black Americans carry variant

What this page does not establish

These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.

Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.

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