Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency is indexed under Respiratory, Genetic Lung Disease. Also known as AATD, alpha-1.
- US prevalence
- ~100,000 severe (PiZZ); many undiagnosed Source: Alpha-1 Foundation; ATS/ERS. This figure comes from a professional society, registry, or study rather than a federal source. Label: REPORTED.
- ICD-10-CM codes
- E88.01
- Typical onset
- Lung disease typically 30-50 years; liver disease any age
- Course
- progressive
- Body systems
- pulmonary, hepatic
- Sex differences
- Equal genetic risk; smoking modifies risk equally
- Racial and ethnic differences
- Most common in Northern European descent
What this page does not establish
These figures describe populations, not individuals, and none of them is a diagnosis or a treatment recommendation. Prevalence estimates are approximate and reflect published ranges. Disparity figures are reported patterns, not causes.
Taxonomy last reviewed 2026-05-19. Each figure on the interactive page carries its own source and retrieval date, which can be later than this review.
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